NORDESTE AND THE UNIVERSITY OF SHIZUOKA BEGIN JOINT RESEARCH TO EXAMINE THE EFFECT OF NMN ON THE SUPPRESSION OF MUSCLE LOSS AND THE IMPROVEMENT OF LIFESTYLE-RELATED DISEASES.

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Nordeste Inc. and the Faculty of Food and Nutritional Sciences of the University of Shizuoka will conduct a joint study to elucidate the effects and mechanisms of NMN on age-related muscle mass loss and lifestyle-related diseases.

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Nordeste, Faculty of Food and Nutritional Sciences, University of Shizuoka Prefecture, regarding joint research.

ASSOCIATE PROFESSOR TETSUYA HOSOOKA AND ASSISTANT PROFESSOR YUKIKO IMI OF THE FACULTY OF FOOD AND NUTRITIONAL SCIENCES AT THE UNIVERSITY OF SHIZUOKA ARE WORKING TO IMPROVE THE QUALITY OF LIFE* OF THE ELDERLY THROUGH RESEARCH ON THE MECHANISM OF AGE-RELATED MUSCLE LOSS. AT THE SAME TIME, SHE IS FOCUSING ON THE CHANGES OBSERVED IN THE ADIPOSE TISSUE OF OBESE PEOPLE, WITH THE GOAL OF DEVELOPING NEW TREATMENT AND PREVENTION METHODS FOR LIFESTYLE-RELATED DISEASES SUCH AS DIABETES CAUSED BY OBESITY. IN COLLABORATION WITH OUR COMPANY, WE WILL CONDUCT A JOINT STUDY TO ELUCIDATE THE EFFECT AND MECHANISM OF NMN (NICOTINAMIDE MONONUCLEOTIDE) ON MUSCLE MASS LOSS AND LIFESTYLE-RELATED DISEASES. *QOL (QUALITY OF LIFE): IN JAPANESE, IT IS TRANSLATED AS "QUALITY OF LIFE" AND MEANS SATISFACTION WITH LIFE AND PURPOSE IN LIFE. FOR THE ELDERLY, MAINTAINING GOOD HEALTH AND LEADING AN INDEPENDENT DAILY LIFE ARE ALSO RELATED TO THE MAINTENANCE OF QOL.

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[Research Background

Recent studies have shown that muscle loss with aging not only reduces athletic performance, but also increases susceptibility to various diseases and shortens life expectancy. This age-related loss of muscle mass and mobility is known as sarcopenia, and is a major problem for Japan's aging population. However, the mechanism of sarcopenia is still unknown, and effective prevention and treatment methods have not been established.
On the other hand, obesity, which is on the rise worldwide, has become a major medical and social problem. Obesity is a state of increased body fat mass, but it has been shown that not only quantity but also quality changes occur in obese adipose tissue. Such changes in the quantity and quality of adipose tissue are thought to be an important cause of lifestyle-related diseases such as diabetes, hypertension, and dyslipidemia, but the detailed mechanisms are unknown.

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Research

Associate Professor Hosooka and his colleagues found that treatment of cultured muscle cells with NMN increased muscle component proteins and muscle cell size. In this joint research, NMN will be administered to aged mice with reduced muscle mass to verify the effects of NMN on muscle mass and strength, and to elucidate the mechanism.
At the same time, Associate Professor Hosooka and his colleagues found that NMN alters the amount of protein in cultured fat cells, which may lead to changes in both quantity and quality of fat. Therefore, this joint research will examine the effects of NMN on the quantity and quality abnormalities observed in the adipose tissue of obese mice, as well as whether changes in the quantity and quality of adipose tissue can improve lifestyle-related diseases such as diabetes mellitus.
As described above, this joint research to verify the efficacy and mechanism of NMN on sarcopenia and lifestyle-related diseases is expected to make a significant contribution to improving the quality of life of elderly people and lifestyle-related diseases.

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[REGARDING NMN IN NORDESTE].

NORDESTE PROVIDES DOMESTICALLY PRODUCED AND HIGH-PURITY NMN POWDER. WE CONTRIBUTE TO THE FUTURE OF HEALTH AND MEDICINE THROUGH ACADEMIC QUALITY RAW MATERIALS USED IN VARIOUS MEDICAL AND RESEARCH INSTITUTIONS.

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Profiles of Principal Investigators

Name: Tetsuya Hosooka

Department of Nutrition and Life Sciences, Faculty of Food and Nutritional Sciences, University of Shizuoka
Associate Professor, Laboratory of Nutritional Physiology

Graduate School of Medicine, Chinese Chinese University
Visiting Associate Professor, Department of Diabetes and Endocrinology (adjunct)

Biography:

• 1994 Graduated from the University of Tokushima, Faculty of Medicine 1994 Trained in internal medicine at Suma Red Cross Hospital and Kobe Rosai Hospital
• 1997 Completed Doctoral program in Internal Medicine, Kobe Medical Center, 2002 Completed Doctoral program in Internal Medicine, Kobe University Graduate School of Medicine, 2002 (Doctor of Medicine)
• 2007 COE RESEARCHER, DEPARTMENT OF DIABETES AND ENDOCRINOLOGY, KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE
• 2008 Postdoctoral Fellow, Beth Israel Medical Center, Harvard University (Professor Barbara Kahn)
• 2010 Project Assistant Professor, Specified Assistant Professor, Assistant Professor, Department of Diabetes and Endocrinology, Kobe University Graduate School of Medicine
• 2019 Lecturer, Department of Internal Medicine, Kobe University Hospital
• 2019 Specially Appointed Associate Professor, Department of Advanced Metabolic Disease Therapy Development, Kobe University Graduate School of Medicine
• 2021 Current position

Metabolism, Nutrition, Diabetes

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Organization

• Nordeste Corporation
• Head Office: 3-5-8 Sekihara, Adachi-ku, Tokyo
• MARUNOUCHI OFFICE: MARUNOUCHI NIJUBASHI BUILDING 2F, 3-2-3 MARUNOUCHI, CHIYODA-KU, TOKYO
• Established: December 1984
• Representative Director: Tomotaka Abe
• Capital: 10 million yen
• URL: https://www.nordeste.co.jp/
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Laboratory of Nutritional Physiology, Department of Nutrition and Life Sciences, Faculty of Food and Nutritional Sciences, University of Shizuoka

Lifestyle habits such as overnutrition and lack of exercise not only increase the amount of adipose tissue, but also cause major qualitative changes in adipose tissue.
The resulting dysfunction of adipose tissue is thought to lead to the formation of various metabolic diseases, including diabetes, dyslipidemia, and nonalcoholic fatty liver disease.
In addition to white adipocytes, which are responsible for energy storage and adipokine secretion, brown adipocytes are responsible for energy consumption through heat production, and beige adipocytes are induced by cold and other stimuli. Using a wide range of analytical methods, including adipocyte-specific gene knockout mice and omics analysis, our laboratory aims to elucidate the metabolic regulation by adipocytes and the mechanisms of metabolic disease development caused by their disruption, and to develop new preventive and therapeutic methods from a nutritional perspective.

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